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King George III

King George III of England

"I was struck by the fact that many of our founding fathers' grievances are the same as those felt today. John Hancock complained that King George III had "forbidden his governors to pass laws of immediate and pressing importance"; "affected to render the military independent of and superior to the civil power"; and perhaps most chillingly, "made judges dependent on his will alone." - Chris Jares

King George III suffered from a genetic disorder called porphyria, an over production of the reddish pigments in hemoglobin, which carry oxygen in red blood cells.

King George III displayed many symptoms of porphyria, including abdominal pain, reddish urine and acute mental disturbances.

Similar symptoms had been reported across several generations of the royal (blue blood megalomaniac) lineage.

Ironically arsenic contaminated medicines used to treat some of his symptoms probably exacerbated them as arsenic disrupts hemoglobin production which, paradoxically, triggers many or porphyria's symptoms.

Biochemist Martin J. Warren of the University of Kent and his colleagues studied five strands of George III's gray hair preserved at London's Science Museum. They concluded that the hair had an arsenic content of 17 times the level generally considered to indicate arsenic poisoning.

"It is extremely likely that his bouts of madness were due to severe porphyric attacks," Martin J. Warren said. "Arsenic may have precipitated his attacks, or made them much more severe."

King George III experienced at least five bouts of extreme derangement, each lasting weeks. King George III occasionally became violent, and he often talked to imaginary people, including a tree he thought was the Prussian king, Frederick II.


There is a very real possibility that had King George III not suffered from severe arsenic poisoning the American colonies would have been dealt with in an entirely different manner and the American Revolution would never have occurred.

"The Declaration, after all, catalogued the assaults on our freedoms committed by Britain's King George III. What has been built up over the last two and a quarter centuries is a structure that dwarfs King George III's regime." – K.E. Grubbs
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