respiratory system

Antiviral potencies of cannabinoids against SARS-CoV-2

Use of Cannabinoids to Treat ARDS and Cytokine Storm

Δ₉-Tetrahydrocannabinol Prevents Mortality from ARDS through the
Induction of Apoptosis in Immune Cells, Leading to Cytokine Storm Suppression

lung function

Cannabinoids inhibit cholinergic contraction in human airways through prejunctional CB₁ receptors

Conclusion: Our present results show that the activation of prejunctional CB₁ receptors inhibits cholinergic contraction in human bronchi.

The effect of phytocannabinoids on airway hyper-responsiveness, airway inflammation, and cough

Conclusion: Cannabis has been demonstrated to have bronchodilator, anti-inflammatory, and antitussive activity in the airways. Only Δ₉-THC demonstrated effects on airway hyper-responsiveness, anti-inflammatory activity, and antitussive activity in the airways.

Antitussive effect of WIN 55212-2, a cannabinoid receptor agonist

Conclusion: The antitussive effect of WIN 55212-2 is mediated by the activation of cannabinoid CB(1) receptors and mu(2) (naloxonazine-insensitive)-opioid receptors, but not mu(1) (naloxonazine-sensitive)- or kappa-opioid receptors.

Cannabidiol improves lung function and inflammation in mice submitted to LPS-induced acute lung injury.

Conclusion: We conclude that CBD administered therapeutically, i.e. during an ongoing inflammatory process, has a potent anti-inflammatory effect and also improves the lung function in mice

Cannabidiol inhibits lung cancer cell invasion and metastasis via intercellular adhesion molecule-1

Conclusion: Overall, our data indicate that cannabinoids induce ICAM-1, thereby conferring TIMP-1 induction and subsequent decreased cancer cell invasiveness.

Δ₉-Tetrahydrocannabinol inhibits epithelial growth factor-induced lung cancer cell migration in vitro as well as its growth and metastasis in vivo

In vivo studies in severe combined immunodeficient mice, there was significant inhibition of the subcutaneous tumor growth and lung metastasis of A549 cells in THC-treated animals as compared to vehicle-treated controls. Tumor samples from THC-treated animals revealed antiproliferative and antiangiogenic effects of THC. Our study suggests that cannabinoids like THC should be explored as novel therapeutic molecules in controlling the growth and metastasis of certain lung cancers.

Cannabinoids increase lung cancer cell lysis by lymphokine-activated large granular lymphocytes via upregulation of ICAM-1

These findings provide proof for a novel antitumorigenic mechanism of cannabinoids.

heart

Marijuana use and short-term outcomes in patients hospitalized for acute myocardial infarction

Marijuana-using patients were significantly less likely to die (OR 0.79, p = 0.016), experience shock (OR 0.74, p = 0.001), or require an IABP (OR 0.80, p = 0.03) post AMI than patients with no reported marijuana use. These results suggest that, contrary to our hypothesis, marijuana use was not associated with increased risk of adverse reactions following AMI. Furthermore, marijuana use was associated with decreased in-hospital mortality post-AMI.

Δ₉-tetrahydrocannabinol protects cardiac cells from hypoxia via CB₂ receptor activation and nitric oxide production

Our findings suggest that THC protects cardiac cells against hypoxia via CB₂ receptor activation by induction of NO production. An NO mechanism occurs also in the classical pre-conditioning process; therefore, THC probably pre-trains the cardiomyocytes to hypoxic conditions.

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