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Synthetic proteins mimic the real thing



Tolerance is a fundamental property of the immune system.

Tolerance involves non-self discrimination which is the ability of the normal immune system to recognize and respond to foreign antigens, but not self.

Autoimmunity is evoked when this tolerance to self antigen is broken.

Immunological tolerance within an individual normally begins as a fetus.

In maternal fetal tolerance T cells express receptors specific for a specific antigen enters the circulation of the developing fetus via the placenta.

Fetal T cells orginate in the bone marrow where they begin growth but must travel to thymus where maturation of T cells occurs.

Within the thymus fetal T cells encounter various self and foreign antigens.

In this manner T cells, attenuated to pathogens, become pathogen hunters.

Approximately 99 percent of fetal T cells die through induction of apoptosis in the thymus in the attempt to convert T cells into pathogen hunters.

An autoimmune response can be incited through molecular mimicry.

Molecular mimicry involves the ability of similar molecular structures from dissimilar genes or proteins to mimic similar organic self structures.

Dissimilar sequence partial structures may elicite an autoimmune response.

Virulent proteins, through molecular surfaces, can mimic host protein surfaces.

Through molecular mimicry a pathogen can generate autoimmunity.

The pathogen may mimic either the linear amino acid sequence or the conformational fit of the immunodominant epitope.

An autoimmune response is then generated by any similar pathogen.

Pathogens alter macrophage function, act as mutagens and cause the release of cytokines.

Due to similar sequence homology in the immunodominant epitope between the pathogen and the host, cells and tissues of the host associated with the protein are hunted down as a result of the autoimmune response.

Findings from biological research suggest that sustained involvement in gratifying activities such as the creation of works of art or walking through Ponderosa pine forests result in positive immune system responses.


Cannabidiol Protects Dopaminergic Neuronal Cells from Cadmium

The protective effect of cannabidiol (CBD), the non-psychoactive component of Cannabis sativa, against neuronal toxicity induced by cadmium chloride (CdCl2 10 µM) was investigated in a retinoic acid (RA)-differentiated SH-SY5Y neuroblastoma cell line. These data showed that Cd-induced neuronal injury was ameliorated by CBD treatment and it was concluded that CBD may represent a potential option to protect neuronal cells from the detrimental effects of Cd toxicity.

Molecular Mechanisms of Cannabinoid Protection from Neuronal Excitotoxicity

Cannabinoids protect neurons from excitotoxic injury. We investigated the mechanisms involved by studying N-methyl-d-aspartate (NMDA) toxicity in cultured murine cerebrocortical neurons in vitro and mouse cerebral cortex in vivo. Cannabinoids seem to protect neurons against NMDA toxicity at least in part by activation of CB1R and downstream inhibition of PKA signaling and NO generation.

Δ9-tetrahydrocannabinol protects hippocampal neurons from excitotoxicity

Cannabinoid receptor agonists act presynaptically to inhibit glutamate release. The effect of prolonged drug exposure on the neuroprotection afforded by cannabinoid receptor agonists was also studied. Desensitization of CB(1) receptors diminishes the neuroprotective effects of cannabinoids. This study demonstrates the importance of agonist efficacy and the duration of treatment on the neuroprotective effects of cannabinoids.

Neuroprotection by Δ9-Tetrahydrocannabinol, the Main Active Compound in Marijuana, against Ouabain-Induced In Vivo Excitotoxicity

In summary, we have shown that in an in vivo model of neurodegeneration Δ9-THC reduces neuronal damage via a CB1-receptor-mediated mechanism. This holds in both the acute and late phase after induction of excitotoxicity. Δ9-THC inhibits astrogliosis via a non-CB1-receptor-controlled mechanism. The results strengthen the concept that the endogenous cannabinoid system may serve to establish a defense system for the brain. This system may be functional in several neurodegenerative diseases in which excitotoxicity is thought to play a role, such as amyotrophic lateral sclerosis, Huntington's and Parkinson's diseases, and also in acute neuronal damage as found in stroke and traumatic brain injury. It is conceivable that the endogenous cannabinoid system can be exploited for therapeutic interventions in these types of primarily incurable diseases.





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This website defines a new perspective with which to engage reality to which its author adheres. The author feels that the falsification of reality outside personal experience has forged a populace unable to discern propaganda from reality and that this has been done purposefully by an international corporate cartel through their agents who wish to foist a corrupt version of reality on the human race. Religious intolerance occurs when any group refuses to tolerate religious practices, religious beliefs or persons due to their religious ideology. This web site marks the founding of a system of philosophy named The Truth of the Way of the Lumière Infinie - a rational gnostic mystery religion based on reason which requires no leap of faith, accepts no tithes, has no supreme leader, no church buildings and in which each and every individual is encouraged to develop a personal relation with the Creator and Sustainer through the pursuit of the knowledge of reality in the hope of curing the spiritual corruption that has enveloped the human spirit. The tenets of the Truth of the Way of the Lumière Infinie are spelled out in detail on this web site by the author. Violent acts against individuals due to their religious beliefs in America is considered a "hate crime."

This web site in no way condones violence. To the contrary the intent here is to reduce the violence that is already occurring due to the international corporate cartels desire to control the human race. The international corporate cartel already controls the world economic system, corporate media worldwide, the global industrial military entertainment complex and is responsible for the collapse of morals, the elevation of self-centered behavior and the destruction of global ecosystems. Civilization is based on coöperation. Coöperation does not occur at the point of a gun.

American social mores and values have declined precipitously over the last century as the corrupt international cartel has garnered more and more power. This power rests in the ability to deceive the populace in general through corporate media by pressing emotional buttons which have been preprogrammed into the population through prior corporate media psychological operations. The results have been the destruction of the family and the destruction of social structures that do not adhere to the corrupt international elites vision of a perfect world. Through distraction and coercion the direction of thought of the bulk of the population has been directed toward solutions proposed by the corrupt international elite that further consolidates their power and which further their purposes.

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