Tolerance is a fundamental property of the immune
Tolerance involves non-self discrimination which is the
ability of the normal immune system to recognize and respond to foreign
antigens, but not self.
Autoimmunity is evoked when this tolerance to
self antigen is broken.
Immunological tolerance within an individual
normally begins as a fetus.
In maternal fetal tolerance T cells express
receptors specific for a specific antigen enters the circulation of the
developing fetus via the placenta.
Fetal T cells orginate in the bone
marrow where they begin growth but must travel to thymus where maturation of T
Within the thymus fetal T cells encounter various self and
In this manner T cells, attenuated to pathogens,
become pathogen hunters.
Approximately 99 percent of fetal T cells die
through induction of apoptosis in the thymus in the attempt to convert T cells
into pathogen hunters.
response can be incited through molecular mimicry.
involves the ability of similar molecular structures from dissimilar genes or
proteins to mimic similar organic self structures.
Dissimilar sequence partial
structures may elicite an autoimmune response.
through molecular surfaces, can mimic host protein surfaces.
molecular mimicry a pathogen can generate autoimmunity.
The pathogen may
mimic either the linear amino acid sequence or the conformational fit of
the immunodominant epitope.
An autoimmune response is then
generated by any similar pathogen.
Pathogens alter macrophage
function, act as mutagens and cause
the release of cytokines.
Due to similar sequence homology in the
immunodominant epitope between the pathogen and the host, cells and tissues of
the host associated with the protein are hunted down as a result of the
Findings from biological research suggest that sustained
involvement in gratifying activities
such as the creation of works of art or walking through Ponderosa pine
forests result in positive immune system responses.
The protective effect of cannabidiol (CBD), the
non-psychoactive component of Cannabis sativa, against neuronal toxicity
induced by cadmium chloride (CdCl2 10 µM) was investigated in a retinoic
acid (RA)-differentiated SH-SY5Y neuroblastoma cell line. These data showed
that Cd-induced neuronal injury was ameliorated by CBD treatment and it was
concluded that CBD may represent a potential option to protect neuronal cells
from the detrimental effects of Cd toxicity.
Cannabinoids protect neurons from excitotoxic
injury. We investigated the mechanisms involved by studying
N-methyl-d-aspartate (NMDA) toxicity in cultured murine cerebrocortical neurons
in vitro and mouse cerebral cortex in vivo. Cannabinoids seem to protect
neurons against NMDA toxicity at least in part by activation of CB1R and
downstream inhibition of PKA signaling and NO generation.
Cannabinoid receptor agonists act presynaptically to
inhibit glutamate release. The effect of prolonged drug exposure on the
neuroprotection afforded by cannabinoid receptor agonists was also studied.
Desensitization of CB(1) receptors diminishes the neuroprotective effects of
cannabinoids. This study demonstrates the importance of agonist efficacy and
the duration of treatment on the neuroprotective effects of cannabinoids.
In summary, we have shown that in an in vivo model
of neurodegeneration Δ9-THC reduces neuronal damage via a
CB1-receptor-mediated mechanism. This holds in both the acute and late phase
after induction of excitotoxicity. Δ9-THC inhibits astrogliosis
via a non-CB1-receptor-controlled mechanism. The results strengthen the concept
that the endogenous cannabinoid system may serve to establish a defense system
for the brain. This system may be functional in several neurodegenerative
diseases in which excitotoxicity is thought to play a role, such as amyotrophic
lateral sclerosis, Huntington's and Parkinson's diseases, and also in acute
neuronal damage as found in stroke and traumatic brain injury. It is
conceivable that the endogenous cannabinoid system can be exploited for
therapeutic interventions in these types of primarily incurable
This web site is not a commercial web site and
is presented for educational purposes only.
This website defines a
new perspective with which to engage reality to which its author adheres. The
author feels that the falsification of reality outside personal experience has
forged a populace unable to discern propaganda from reality and that this has
been done purposefully by an international corporate cartel through their
agents who wish to foist a corrupt version of reality on the human race.
Religious intolerance occurs when any group refuses to tolerate religious
practices, religious beliefs or persons due to their religious ideology. This
web site marks the founding of a system of philosophy named The Truth of the
Way of the Lumière Infinie - a rational gnostic mystery religion based
on reason which requires no leap of faith, accepts no tithes, has no supreme
leader, no church buildings and in which each and every individual is
encouraged to develop a personal relation with the Creator and Sustainer
through the pursuit of the knowledge of reality in the hope of curing the
spiritual corruption that has enveloped the human spirit. The tenets of the
Truth of the Way of the Lumière Infinie are spelled out in detail on
this web site by the author. Violent acts against individuals due to their
religious beliefs in America is considered a "hate crime."
This web site
in no way condones violence. To the contrary the intent here is to reduce the
violence that is already occurring due to the international corporate cartels
desire to control the human race. The international corporate cartel already
controls the world economic system, corporate media worldwide, the global
industrial military entertainment complex and is responsible for the collapse
of morals, the elevation of self-centered behavior and the destruction of
global ecosystems. Civilization is based on coöperation. Coöperation
does not occur at the point of a gun.
American social mores and values
have declined precipitously over the last century as the corrupt international
cartel has garnered more and more power. This power rests in the ability to
deceive the populace in general through corporate media by pressing emotional
buttons which have been preprogrammed into the population through prior
corporate media psychological operations. The results have been the destruction
of the family and the destruction of social structures that do not adhere to
the corrupt international elites vision of a perfect world. Through distraction
and coercion the direction of thought of the bulk of the population has been
directed toward solutions proposed by the corrupt international elite that
further consolidates their power and which further their purposes.
views and opinions presented on this web site are the views and opinions of
individual human men and women that, through their writings, showed the
capacity for intelligent, reasonable, rational, insightful and unpopular
thought. All factual information presented on this web site is believed to be
true and accurate and is presented as originally presented in print media which
may or may not have originally presented the facts truthfully. Opinion and
thoughts have been adapted, edited, corrected, redacted, combined, added to,
re-edited and re-corrected as nearly all opinion and thought has been
throughout time but has been done so in the spirit of the original writer with
the intent of making his or her thoughts and opinions clearer and relevant to
the reader in the present time.
Fair Use Notice
This site may contain copyrighted material the use of which has
not always been specifically authorized by the copyright owner. We are making
such material available in our efforts to advance understanding of criminal
justice, human rights, political, economic, democratic, scientific, and social
justice issues, etc. We believe this constitutes a 'fair use' of any such
copyrighted material as provided for in section 107 of the US Copyright Law. In
accordance with Title 17 U.S.C. Section 107, the material on this site is
distributed without profit to those who have expressed a prior interest in
receiving the included information for research and educational purposes. For
more information see: www.law.cornell.edu/uscode/17/107.shtml. If you wish to
use copyrighted material from this site for purposes of your own that go beyond
'fair use', you must obtain permission from the copyright owner.
© Lawrence Turner
All Rights Reserved