Tolerance is a fundamental property of the immune
Tolerance involves non-self discrimination which is the
ability of the normal immune
system to recognize and respond to foreign
antigens, but not
Autoimmunity is evoked when this tolerance to self antigen is
tolerance within an individual normally begins as a fetus.
maternal fetal tolerance T cells express receptors specific for a specific
antigen enters the circulation of the developing fetus via the
Fetal T cells orginate in the bone marrow where they begin
growth but must travel to thymus where maturation of T cells
Within the thymus fetal T cells encounter various self and
In this manner T cells, attenuated to pathogens,
become pathogen hunters.
Approximately 99 percent of fetal T cells die
through induction of apoptosis in the thymus in the attempt to convert T cells
into pathogen hunters.
An autoimmune response can
be incited through molecular mimicry.
Molecular mimicry involves the
ability of similar molecular structures from dissimilar genes or
proteins to mimic similar
organic self structures.
Dissimilar sequence partial
structures may elicite an autoimmune response.
Virulent proteins, through
molecular surfaces, can mimic host protein
Through molecular mimicry a pathogen can generate
The pathogen may mimic
either the linear amino acid sequence or the conformational fit of the
autoimmune response is then generated by any similar pathogen.
Pathogens alter macrophage function, act as
cause the release of cytokines.
Due to similar sequence homology in the
immunodominant epitope between the pathogen and the host, cells and tissues of
the host associated with the protein are hunted down as a result of the
Findings from biological research suggest that sustained
involvement in gratifying activities
such as the creation of works of art or walking through Ponderosa pine
forests result in positive immune system
The protective effect of cannabidiol (CBD), the
non-psychoactive element of Cannabis sativa, against neuronal toxicity induced
by cadmium chloride (CdCl2 10 µM) was investigated in a retinoic acid
(RA)-differentiated SH-SY5Y neuroblastoma cell line. These data showed that
Cd-induced neuronal injury was ameliorated by CBD treatment and it was
concluded that CBD may represent a potential option to protect neuronal cells
from the detrimental effects of Cd toxicity.
Cannabinoids protect neurons from excitotoxic
injury. We investigated the mechanisms involved by studying
N-methyl-d-aspartate (NMDA) toxicity in cultured murine cerebrocortical neurons
in vitro and mouse cerebral cortex in vivo. Cannabinoids seem to protect
neurons against NMDA toxicity at least in part by activation of CB1R and
downstream inhibition of PKA signaling and NO generation.
Cannabinoid receptor agonists act presynaptically to
inhibit glutamate release. The effect
of prolonged drug exposure on the neuroprotection afforded by cannabinoid
receptor agonists was also studied. Desensitization of CB(1) receptors
diminishes the neuroprotective effects of cannabinoids. This study demonstrates
the importance of agonist efficacy and the duration of treatment on the
neuroprotective effects of cannabinoids.
In summary, we have shown that in an in vivo model
of neurodegeneration Δ9-THC reduces neuronal damage via a
CB1-receptor-mediated mechanism. This holds in both the acute and
late phase after induction of excitotoxicity. Δ9-THC inhibits
astrogliosis via a non-CB1-receptor-controlled mechanism. The
results strengthen the concept that the endogenous cannabinoid system may serve
to establish a defense system for the brain. This system may be functional in
several neurodegenerative diseases in which excitotoxicity is thought to play a
role, such as amyotrophic lateral sclerosis, Huntington's and Parkinson's
diseases, and also in acute
neuronal damage as found in stroke and traumatic brain injury. It is
conceivable that the endogenous cannabinoid system can be exploited for
therapeutic interventions in these types of primarily incurable
This web site is not a commercial web site and
is presented for educational purposes only.
This website defines a
new perspective with which to engage reality to which its author adheres. The
author feels that the falsification of reality outside personal experience has
forged a populace unable to discern propaganda from reality and that this has
been done purposefully by an international corporate cartel through their
agents who wish to foist a corrupt version of reality on the human race.
Religious intolerance occurs when any group refuses to tolerate religious
practices, religious beliefs or persons due to their religious ideology. This
web site marks the founding of a system of philosophy named The Truth of the
Way of the Lumière Infinie - a rational gnostic mystery religion based
on reason which requires no leap of faith, accepts no tithes, has no supreme
leader, no church buildings and in which each and every individual is
encouraged to develop a personal relation with the Creator and Sustainer
through the pursuit of the knowledge of reality in the hope of curing the
spiritual corruption that has enveloped the human spirit. The tenets of the
Truth of the Way of the Lumière Infinie are spelled out in detail on
this web site by the author. Violent acts against individuals due to their
religious beliefs in America is considered a "hate crime."
This web site
in no way condones violence. To the contrary the intent here is to reduce the
violence that is already occurring due to the international corporate cartels
desire to control the human race. The international corporate cartel already
controls the world economic system, corporate media worldwide, the global
industrial military entertainment complex and is responsible for the collapse
of morals, the elevation of self-centered behavior and the destruction of
global ecosystems. Civilization is based on coöperation. Coöperation
does not occur at the point of a gun.
American social mores and values
have declined precipitously over the last century as the corrupt international
cartel has garnered more and more power. This power rests in the ability to
deceive the populace in general through corporate media by pressing emotional
buttons which have been preprogrammed into the population through prior
corporate media psychological operations. The results have been the destruction
of the family and the destruction of social structures that do not adhere to
the corrupt international elites vision of a perfect world. Through distraction
and coercion the direction of thought of the bulk of the population has been
directed toward solutions proposed by the corrupt international elite that
further consolidates their power and which further their purposes.
views and opinions presented on this web site are the views and opinions of
individual human men and women that, through their writings, showed the
capacity for intelligent, reasonable, rational, insightful and unpopular
thought. All factual information presented on this web site is believed to be
true and accurate and is presented as originally presented in print media which
may or may not have originally presented the facts truthfully. Opinion and
thoughts have been adapted, edited, corrected, redacted, combined, added to,
re-edited and re-corrected as nearly all opinion and thought has been
throughout time but has been done so in the spirit of the original writer with
the intent of making his or her thoughts and opinions clearer and relevant to
the reader in the present time.
Fair Use Notice
This site may contain
copyrighted material the use of which has not always been specifically
authorized by the copyright owner. We are making such material available in our
efforts to advance understanding of criminal justice, human rights, political,
economic, democratic, scientific, and social justice issues, etc. We believe
this constitutes a 'fair use' of any such copyrighted material as provided for
in section 107 of the US Copyright Law. In accordance with Title 17 U.S.C.
Section 107, the material on this site is distributed without profit to those
who have expressed a prior interest in receiving the included information for
research and educational purposes. For more information see:
www.law.cornell.edu/uscode/17/107.shtml. If you wish to use copyrighted
material from this site for purposes of your own that go beyond 'fair use', you
must obtain permission from the copyright owner.
© Lawrence Turner
All Rights Reserved