stacks



gastrointestinal system

chronic liver disease

kidney fibrosis

nausea

colitis

Crohn's


Cannabinoids in intestinal inflammation and cancer.

Conclusion: Pharmacological elevation of endocannabinoid levels may be a promising strategy to counteract intestinal inflammation and colon cancer.

Members of the endocannabinoid system are distinctly regulated in inflammatory bowel disease and colorectal cancer

The two forms of IBD, ulcerative colitis (UC) and Crohn’s disease (CD) have rapidly increased in the past years in Western countries ranging at a prevalence of more than 200 cases per 100,000 inhabitants.

chronic liver disease

The role of the endocannabinoid system in liver diseases

Conclusion: The EC system is strongly up-regulated during chronic liver diseases. Until now it has been implicated in the pathogenesis of fatty liver disease associated with obesity, alcohol abuse, and hepatitis C, in the progression of fibrosis to cirrhosis, and in the development of portal hypertension, hyperdynamic circulatory syndrome and its complications, and cirrhotic cardiomyopathy. Furthermore, the EC system can participate in the pathogenesis of acute liver injury by modulating the mechanisms responsible for cell injury and inflammatory response. Thus, targeting the CB1 and CB2 receptors represents a potential therapeutic goal for the treatment of liver diseases.

Cannabinoid receptors as new targets of antifibrosing strategies during chronic liver diseases

Conclusion: Endocannabinoid-based therapies, combining CB2 agonists and CB1 antagonists may open novel therapeutic perspectives for the treatment of chronic liver diseases.

The endocannabinoid system as a key mediator during liver diseases

Conclusion: CB1 receptors have been implicated in the pathogenesis of several lesions such as liver fibrogenesis, alcoholic and metabolic steatosis, or circulatory failure associated with cirrhosis. In contrast, stimulation of hepatic CB2 receptors is emerging as an overall protective pathway with antifibrogenic properties and beneficial effects on liver inflammation, alcoholic fatty liver and hepatocyte survival and regeneration.

Beneficial paracrine effects of cannabinoid receptor 2 on liver injury and regeneration

Conclusion: CB2 receptors reduce liver injury and promote liver regeneration following acute insult, via distinct paracrine mechanisms involving hepatic myofibroblasts.

CB1 cannabinoid receptor antagonism: a new strategy for the treatment of liver fibrosis

Conclusion: Our study shows that CB1 receptor antagonists hold promise for the treatment of liver fibrosis.

Cannabidiol protects liver from binge alcohol-induced steatosis

Conclusion: CBD can alleviate lipid accumulation in both an in vitro HepG2 cell model and an in vivo binge alcohol treatment model by multiple mechanisms.

Cannabinoid CB2 receptors protect against alcoholic liver disease by regulating Kupffer cell polarization

Conclusion: These findings demonstrate that CB2 receptors display beneficial effects on alcohol-induced inflammation by regulating M1/M2 balance in Kupffer cells, thereby reducing hepatocyte steatosis via paracrine interactions between Kupffer cells and hepatocytes.

Two non-psychoactive cannabinoids reduce intra-cellular lipid levels and inhibit hepatosteatosis

Conclusion: Our results suggest that THCV and CBD might be used as new therapeutic agents for the pharmacological treatment of obesity- and metabolic syndrome-related NAFLD/hepatosteatosis


nausea

Cannabinoids suppress acute and anticipatory nausea

Conclusion: Cannabinoids have great promise as treatments for nausea and that their anti-nausea effects may be mediated by the interoceptive insular cortex.

Regulation of nausea and vomiting by cannabinoids

Conclusion: This model may be a useful tool for elucidating the neurobiology of nausea and the role that the endocannabinoid system plays in the regulation of this distressing condition.

Regulation of nausea and vomiting by cannabinoids

Conclusion: Future efforts aimed at developing new endocannabinoid-based anti-nausea and anti-emetic therapies are clearly warranted.


kidney fibrosis

Expression of cannabinoid receptors in human kidney

Conclusion: Our data suggest a possible implication of the endocannabinoid system in the physiology and development of the human kidney.

Cannabinoid receptor 1 is a major mediator of renal fibrosis

Conclusion: CB1 has a major role in the activation of myofibroblasts and may be a new target for treating chronic kidney disease.


colitis

Cannabidiol, a safe and non-psychotropic ingredient of the marijuana plant Cannabis sativa, is protective in a murine model of colitis

Cannabidiol, a safe and non-psychotropic ingredient of marijuana, exerts pharmacological effects (e.g., antioxidant) and mechanisms (e.g., inhibition of endocannabinoids enzymatic degradation) potentially beneficial for the inflamed gut.


Crohn's

Cannabis induces a clinical response in patients with Crohn's disease

Conclusion: A short course (8 weeks) of THC-rich cannabis produced significant clinical, steroid-free benefits to 10 of 11 patients with active Crohn's disease, compared with placebo, without side effects.





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