Lilly begins its off-label marketing push,
the only approved use of Zyprexa® is for patients suffering from
Even so Eli
Lilly encouraged physicians to prescribe Zyprexa® to elderly
patients with early signs of
Lilly urged physicians to prescribe Zyprexa® for
elderly patients with dementia, an
unapproved use for the antiPsychotic, even though the chemicalmaker had
evidence the medicine didn't work for such patients." - Margaret Cronin Fisk,
Elizabeth Lopatto and Jef Feeley
discoversZyprexa®, a chemical
designed to treat bipolar disorder
and schizophrenia, causes excessive weight gain in patients leading to
2002 British and Japanese regulatory agencies issue a warning:
Zyprexa® may cause diabetes.
2003 FDA issues a warning but
Eli Lilly does not pull
Zyprexa® from the market.
This becomes all the more understandable
after it is taken into consideration that
Eli Lilly is also the
largest maker of diabetes
medications." - Dr. Doug Henderson and Dr. Gary Null
2005 In the first class action
filed over Zyprexa® Eli Lilly settled with
8000 plaintiffs for $700 million in 2005.
The settlement requires that all
sensitive documents be sealed.
Eli Lilly sells $4.2 billion
worth of Zyprexa®.
2007 Eli Lilly
settles with another 18,000 plaintiffs who sued over the adverse effects of
Zyprexa® after the first trial documents were publicized by a third party
unrelated to the original settlement.
2008 Zyprexa® is the best-selling Eli Lilly chemical, with
$4.7 billion in sales.
American chemical sales in 2008 garnering $14.6 billion.
that Zyprexa®, made by Eli Lilly, and Risperdal®, made by
Janssen are no more effective than earlier
they were marketed as being better because they reduced
side effects such as uncontrolled
shaking or tremors - the effects of
agrees to pay $1.42 billion to settle criminal ($615 million) and civil charges
($800 million) related to the off-label
marketing of its
antiPsychotic chemical Zyprexa®.
admitted to promoting Zyprexa® for unapproved,
off-label uses between 1999 and
2001, including for treatment of dementia in
Zyprexa® "has been Lilly's top-selling
chemical, garnering the incorporation more than $37 billion in world-wide sales
since its US approval in 1996," according to the Wall Street
Drug-Induced Dementia isnt
Popular Drugs Linked To Dementia At Low
The FDA has
reports of diarrhea so
severe, called ischemic colitis, in users of the irritable-bowel treatment
Zelnorm® that it caused such complications as
pressure and fainting.
The FDA has received 20 reports of ischemic
colitis, since Zelnorm® went on sale in 2002, fourteen patients were
hospitalized, four died.
The Food and Drug Administration
advised patients who experience new or worsened abdominal pain or blood in
their stools to stop taking the chemical and call a doctor.
Research released in
late 2005 shows that an individual that uses the popular prescription heartburn
drugs - Prilosec®, Prevacid®, and Nexium® - are more prone to
getting a potentially dangerously severe
diarrhea caused by clostridium
In December 2006 the
Journal of the
American Medical Association reported that the use of Nexium®,
Prilosec®, Prevacid®, Protinix® reduces calcium absorption in the
small intestine resulting in increased risk of hip fractures.
users had 260% the average risk of hip fracture.
Zicam® 2006 Matrixx, the manufacturer of Zicam®, pays $12 million
to settle 340 lawsuits from Zicam® users who claimed that the product
destroyed their sense of smell, a condition known as anosmia.
more such suits have since been filed.
Reports of destroyed sense of
smell started in 1999.
Zonegran®FDA has warned that the
Zonegran® can cause a certain type of metabolic disorder that can increase
the risk of kidney stones and bone
The FDA said physicians need to be aware that
treatment with zonisamide can cause metabolic acidosis, a disturbance in the
body's acid-base balance that results in excessive acidity of the blood.
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