Lilly begins its off-label marketing push,
the only approved use of Zyprexa® is for patients suffering from
Even so Eli
Lilly encouraged physicians to prescribe Zyprexa® to elderly
patients with early signs of dementia.
"Eli Lilly urged physicians to
prescribe Zyprexa® for elderly patients with dementia, an unapproved use
for the antiPsychotic, even though the chemicalmaker had evidence the medicine
didn't work for such patients." - Margaret Cronin Fisk, Elizabeth Lopatto and
discoversZyprexa®, a chemical
designed to treat bipolar disorder
and schizophrenia, causes excessive weight gain in patients leading to
2002 British and Japanese regulatory agencies issue a warning:
Zyprexa® may cause diabetes.
2003 FDA issues a warning but
Eli Lilly does not pull
Zyprexa® from the market.
This becomes all the more understandable
after it is taken into consideration that
Eli Lilly is also the
largest maker of diabetes medications." - Dr. Doug Henderson and Dr. Gary
2005 In the first
class action filed over Zyprexa® Eli Lilly settled with
8000 plaintiffs for $700 million in 2005.
The settlement requires that all
sensitive documents be sealed.
Eli Lilly sells $4.2 billion
worth of Zyprexa®.
2007 Eli Lilly
settles with another 18,000 plaintiffs who sued over the adverse effects of
Zyprexa® after the first trial documents were publicized by a third party
unrelated to the original settlement.
2008 Zyprexa® is the best-selling Eli Lilly chemical, with
$4.7 billion in sales.
American chemical sales in 2008 garnering $14.6 billion.
that Zyprexa®, made by Eli Lilly, and Risperdal®, made by
Janssen are no more effective than earlier
they were marketed as being better because they reduced
side effects such as uncontrolled
shaking or tremors - the effects of
agrees to pay $1.42 billion to settle criminal ($615 million) and civil charges
($800 million) related to the off-label
marketing of its
antiPsychotic chemical Zyprexa®.
admitted to promoting Zyprexa® for unapproved,
off-label uses between 1999 and
2001, including for treatment of dementia in elderly populations.
Zyprexa® "has been Lilly's top-selling chemical, garnering the
incorporation more than $37 billion in world-wide sales since its US approval
in 1996," according to the Wall
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