Zyprexa®

1999Eli Lilly begins its off-label marketing push, the only approved use of Zyprexa® is for patients suffering from schizophrenia.

Even so Eli Lilly encouraged physicians to prescribe Zyprexa® to elderly patients with early signs of dementia.

"Eli Lilly urged physicians to prescribe Zyprexa® for elderly patients with dementia, an unapproved use for the antiPsychotic, even though the chemicalmaker had evidence the medicine didn't work for such patients." - Margaret Cronin Fisk, Elizabeth Lopatto and Jef Feeley

This year Eli Lilly discoversZyprexa®, a chemical designed to treat bipolar disorder and schizophrenia, causes excessive weight gain in patients leading to diabetes.

2002 British and Japanese regulatory agencies issue a warning: Zyprexa® may cause diabetes.

2003 FDA issues a warning but Eli Lilly does not pull Zyprexa® from the market.

This becomes all the more understandable after it is taken into consideration that Eli Lilly is also the largest maker of diabetes medications." - Dr. Doug Henderson and Dr. Gary Null

2005 In the first class action filed over Zyprexa® Eli Lilly settled with 8000 plaintiffs for $700 million in 2005.

The settlement requires that all sensitive documents be sealed.

Eli Lilly sells $4.2 billion worth of Zyprexa®.

2007 Eli Lilly settles with another 18,000 plaintiffs who sued over the adverse effects of Zyprexa® after the first trial documents were publicized by a third party unrelated to the original settlement.

2008 Zyprexa® is the best-selling Eli Lilly chemical, with $4.7 billion in sales.

AntiPsychotics top American chemical sales in 2008 garnering $14.6 billion.

Study confirms that Zyprexa®, made by Eli Lilly, and Risperdal®, made by Janssen are no more effective than earlier antiPsychotics.

Initially they were marketed as being better because they reduced side effects such as uncontrolled shaking or tremors - the effects of tardive dyskinesia.

2009 Eli Lilly agrees to pay $1.42 billion to settle criminal ($615 million) and civil charges ($800 million) related to the off-label marketing of its antiPsychotic chemical Zyprexa®.

Eli Lilly admitted to promoting Zyprexa® for unapproved, off-label uses between 1999 and 2001, including for treatment of dementia in elderly populations.

Zyprexa® "has been Lilly's top-selling chemical, garnering the incorporation more than $37 billion in world-wide sales since its US approval in 1996," according to the Wall Street Journal.

Zelnorm®

The FDA has reports of diarrhea so severe, called ischemic colitis, in users of the irritable-bowel treatment Zelnorm® that it caused such complications as low blood pressure and fainting.

The FDA has received 20 reports of ischemic colitis, since Zelnorm® went on sale in 2002, fourteen patients were hospitalized, four died.

The Food and Drug Administration advised patients who experience new or worsened abdominal pain or blood in their stools to stop taking the chemical and call a doctor.

Research released in late 2005 shows that an individual that uses the popular prescription heartburn drugs - Prilosec®, Prevacid®, and Nexium® - are more prone to getting a potentially dangerously severe diarrhea caused by clostridium difficile bacteria.

In December 2006 the Journal of the American Medical association reported that the use of Nexium®, Prilosec®, Prevacid®, Protinix® reduces calcium absorption in the small intestine resulting in increased risk of hip fractures.

Long term users had 260% the average risk of hip fracture.

Zicam®

2006 Matrixx, the manufacturer of Zicam®, pays $12 million to settle 340 lawsuits from Zicam® users who claimed that the product destroyed their sense of smell, a condition known as anosmia.

Hundreds more such suits have since been filed.

Reports of destroyed sense of smell started in 1999.

Zonegran®

FDA has warned that the epilepsy chemical Zonegran® can cause a certain type of metabolic disorder that can increase the risk of kidney stones and bone diseases.

The FDA said physicians need to be aware that treatment with zonisamide can cause metabolic acidosis, a disturbance in the body's acid-base balance that results in excessive acidity of the blood.

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