Lilly begins its off-label marketing push,
the only approved use of Zyprexa® is for patients suffering from
Even so Eli
Lilly encouraged physicians to prescribe Zyprexa® to elderly
patients with early signs of dementia.
"Eli Lilly urged physicians to
prescribe Zyprexa® for elderly patients with dementia, an unapproved use
for the antiPsychotic, even though the chemicalmaker had evidence the medicine
didn't work for such patients." - Margaret Cronin Fisk, Elizabeth Lopatto and
discoversZyprexa®, a chemical
designed to treat bipolar disorder
and schizophrenia, causes excessive weight gain in patients leading to
2002 British and Japanese regulatory agencies issue a warning:
Zyprexa® may cause diabetes.
2003 FDA issues a warning but
Eli Lilly does not pull
Zyprexa® from the market.
This becomes all the more understandable
after it is taken into consideration that
Eli Lilly is also the
largest maker of diabetes medications." - Dr. Doug Henderson and Dr. Gary
2005 In the first
class action filed over Zyprexa® Eli Lilly settled with
8000 plaintiffs for $700 million in 2005.
The settlement requires that all
sensitive documents be sealed.
Eli Lilly sells $4.2 billion
worth of Zyprexa®.
2007 Eli Lilly
settles with another 18,000 plaintiffs who sued over the adverse effects of
Zyprexa® after the first trial documents were publicized by a third party
unrelated to the original settlement.
2008 Zyprexa® is the best-selling Eli Lilly chemical, with
$4.7 billion in sales.
American chemical sales in 2008 garnering $14.6 billion.
that Zyprexa®, made by Eli Lilly, and Risperdal®, made by
Janssen are no more effective than earlier
they were marketed as being better because they reduced
side effects such as uncontrolled
shaking or tremors - the effects of
agrees to pay $1.42 billion to settle criminal ($615 million) and civil charges
($800 million) related to the off-label
marketing of its
antiPsychotic chemical Zyprexa®.
admitted to promoting Zyprexa® for unapproved,
off-label uses between 1999 and
2001, including for treatment of dementia in elderly populations.
Zyprexa® "has been Lilly's top-selling chemical, garnering the
incorporation more than $37 billion in world-wide sales since its US approval
in 1996," according to the Wall
The FDA has reports of
diarrhea so severe,
called ischemic colitis, in users of the irritable-bowel treatment Zelnorm®
that it caused such complications as
pressure and fainting.
The FDA has received 20 reports of ischemic
colitis, since Zelnorm® went on sale in 2002, fourteen patients were
hospitalized, four died.
The Food and Drug Administration
advised patients who experience new or worsened abdominal pain or blood in
their stools to stop taking the chemical and call a doctor.
Research released in
late 2005 shows that an individual that uses the popular prescription heartburn
drugs - Prilosec®, Prevacid®, and Nexium® - are more prone to
getting a potentially dangerously severe
diarrhea caused by clostridium difficile
In December 2006 the Journal of the American Medical
association reported that the use of Nexium®, Prilosec®, Prevacid®,
Protinix® reduces calcium absorption in the small intestine resulting in
increased risk of hip fractures.
Long term users had 260% the average
risk of hip fracture.
Zicam® 2006 Matrixx, the manufacturer of Zicam®, pays $12 million
to settle 340 lawsuits from Zicam® users who claimed that the product
destroyed their sense of smell, a condition known as anosmia.
more such suits have since been filed.
Reports of destroyed sense of
smell started in 1999.
Zonegran®FDA has warned that the
Zonegran® can cause a certain type of metabolic disorder that can increase
the risk of kidney stones and bone
The FDA said physicians need to be aware that
treatment with zonisamide can cause metabolic acidosis, a disturbance in the
body's acid-base balance that results in excessive acidity of the blood.
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