1999Eli Lilly begins its
off-label marketing push,
the only approved use of Zyprexa® is for patients suffering from
Even so Eli
Lilly encouraged physicians to prescribe Zyprexa® to elderly
patients with early signs of
urged physicians to prescribe Zyprexa® for
elderly patients with
dementia, an unapproved use for the antiPsychotic, even though the
chemicalmaker had evidence the medicine didn't work for such patients." -
Margaret Cronin Fisk, Elizabeth Lopatto and Jef Feeley
discovers Zyprexa®, a chemical designed to treat
bipolar disorder and
schizophrenia, causes excessive weight gain in patients leading to
2002 British and Japanese regulatory agencies issue a warning:
Zyprexa® may cause diabetes.
2003 FDA issues a warning but
Eli Lilly does not pull
Zyprexa® from the market.
This becomes all the more understandable
after it is taken into consideration that
Eli Lilly is also the
largest maker of diabetes
medications." - Dr. Doug Henderson and Dr. Gary Null
2005 In the first class action filed over Zyprexa® Eli Lilly settled with
8000 plaintiffs for $700 million in 2005.
The settlement requires
that all sensitive documents be sealed.
Eli Lilly sells $4.2
billion worth of Zyprexa®.
Lilly settles with another 18,000 plaintiffs who sued over the adverse
effects of Zyprexa® after the first trial documents were publicized by a
third party unrelated to the original settlement.
2008 Zyprexa® is the best-selling Eli Lilly chemical, with
$4.7 billion in sales.
American chemical sales in 2008 garnering $14.6 billion.
that Zyprexa®, made by Eli Lilly, and Risperdal®, made by
Janssen are no more effective than earlier
Initially they were marketed as being better because they reduced
side effects such as uncontrolled
shaking or tremors - the effects of tardive dyskinesia.
agrees to pay $1.42 billion to settle criminal ($615 million) and civil charges
($800 million) related to the off-label
its antiPsychotic chemical Zyprexa®.
Eli Lilly admitted to promoting
Zyprexa® for unapproved, off-label uses between 1999 and 2001,
including for treatment of dementia
in elderly populations.
Zyprexa® "has been Lilly's top-selling
chemical, garnering the incorporation more than $37 billion in world-wide sales
since its US approval in 1996," according to the Wall Street
Drug-Induced Dementia isnt
Popular Drugs Linked To Dementia At Low
The FDA has
reports of diarrhea
so severe, called ischemic colitis, in users of the irritable-bowel
treatment Zelnorm® that it caused such complications as
low blood pressure and
The FDA has received 20 reports of ischemic colitis, since
Zelnorm® went on sale in 2002, fourteen patients were hospitalized, four
The Food and Drug Administration advised patients who
experience new or worsened abdominal pain or blood in their stools to stop
taking the chemical and call a doctor.
Research released in late 2005
shows that an individual that uses the popular prescription heartburn drugs -
Prilosec®, Prevacid®, and Nexium® - are more prone to getting
a potentially dangerously severe diarrhea
caused by clostridium
In December 2006 the
Journal of the American Medical Association reported that the use of Nexium®,
Prilosec®, Prevacid®, Protinix® reduces calcium absorption in the
small intestine resulting in increased risk of hip fractures.
users had 260% the average risk of hip fracture.
Zicam® 2006 Matrixx, the manufacturer of Zicam®, pays $12 million
to settle 340 lawsuits from Zicam® users who claimed that the product
destroyed their sense of smell, a condition known as anosmia.
more such suits have since been filed.
Reports of destroyed sense of
smell started in 1999.
Zonegran®FDA has warned that the
Zonegran® can cause a certain type of metabolic disorder that can increase
the risk of kidney stones and bone
The FDA said physicians need to be aware that
treatment with zonisamide can cause metabolic acidosis, a disturbance in the
body's acid-base balance that results in excessive acidity of the blood.
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