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"If you look at the chemical war from a purely
economic point of view, the role of the government is to protect the chemical
cartel." - Milton
Friedman
"If you aren't
happy in your work, that
must imply a fault in your
production process (socialization, education, training); fortunately, that
can be adjusted with pharmaceutical technology." - Charles Eisenstein
antiDepressant increase the risk
compared to placebo of
suicidal thinking and behavior (suicidality) in children, adolescents, and
young adults in short-term studies of major depressive disorder (MDD) and other
psychiatric disorders.
Anyone considering the use of [insert name of
pharmaceutical profit center blockbuster] or any other antidepressant in a
child, adolescent, or young adult must
balance this risk with the
clinical need.
"A review of seventy-four
clinical trials of
antiDepressant found that thirty-seven of thirty-eight positive studies [that
praised the chemicals] were published. But of the thirty-six negative studies,
thirty-three were either not published or published in a form that conveyed a
positive outcome." - Marcia Angell, MD,
Executive Editor New England
Journal of Medicine
2004
FDA revises labeling requirements for
antiDepressant:
"SELECTIVE SEROTONIN REUPTAKE INHIBITOR induced
apathy is generally marked by a lack of motivation that is
not a result of sedation,
change in level of
consciousness, or symptoms of
a mood disorder (Barnhart et al. 2004; Hoehn-Saric et al. 1990; Marin
1991).
The term apathy is usually defined as a lack of self-initiated
responsiveness to stimuli or lack of motivation (Marin 1991; van Reekum et al.
2005).
Apathy, amotivational syndrome, has mainly been reported in
adults taking SSRIs (Barnhart et al., 2004; Hoehn-Saric et al., 1990), although
a few adolescents - and even fewer children - have been described (Garland and
Baerg 2001).
Several names have been used to describe this phenomenon,
including SSRI-induced apathy, amotivation, emotional blunting, and
drug-induced indifference (Balon 2002; Garland and Baerg 2001; Hoehn-Saric et
al. 1990; Riddle et al. 1991).
This SSRI
adverse reaction
(AE) is easily missed or ascribed to underlying psychopathology and
misinterpreted as medication failure, particularly in depressed patients
(Garland and Baerg 2001).
This clinical error can sometimes prompt
medication dose increases, with consequent
exacerbation of the
apathy." - Selective Serotonin Reuptake Inhibitor Induced Apathy: A
Pediatric Case Series Shauna P. Reinblatt, M.D., FRCPC, and Mark A. Riddle,
Journal of Child and Adolescent Psychopharmacology Volume 16, Number
1/2, 2006 Mary Ann Liebert, Inc. Pp. 227–233
serotonin = 5-hydroxytryptamine
tryptophan =
5-hydroxytryptophan
dopamine =
3,4-dihydroxyphenethylamine
melatonin = N-acetyl-5-methoxy
tryptamine
norepinephrine =
noradrenaline = 1,2-Benzenediol,
4-(2-amino-1-hydroxyethyl)
epinephrine = adrenaline = 1,2-Benzenediol,
4-[(1R)-1-hydroxy-2-(methylamino)ethyl]
"All the selective serotonin reuptake inhibitors
[including Prozac® and Luvox®] relieve the patient of feeling.
He becomes less empathic, as in
I don't care as much,' which means
'It's easier for me to
harm you.'
If a doctor treats someone who needs a great deal of
strength just to think straight, and gives him one of these chemicals, that
could push him over the edge into violent behavior." - Dr. Joseph Tarantolo,
American Society of Psychoanalytic Physicians
5 of the top 10 violence-inducing chemicals are
antiDepressant:
fluoxetine (Prozac®)
paroxetine (Paxil®)
fluvoxamine (Luvox®)
venlafaxine (Effexor®)
desvenlafaxine
(Pristiq®)
Antidepressant prescribing has risen
nearly 400% since 1988,
according to data from the Centers for Disease Control
From 1999 to 2012 the percentage of Americans on
antiDepressant increased from 6.8% to 13%,
according to a report published
this week by the Journal of
the American Medical Association (JAMA).
Selective serotonin reuptake inhibitors ( SSRI) increase the
extracellular level of the neurotransmitter serotonin
by inhibiting its reuptake into the presynaptic cell, increasing the level of
serotonin available to bind to the postsynaptic receptor.
It is
generally thought that tricyclic antiDepressant work by inhibiting the
re-uptake of the neurotransmitters
norepinephrine and serotonin.
"Since it has been suggested that the OFC
is critically involved in both reversal learning and delayed
pattern recognition
(Rogers et al. 1999a; Rubinsztein et al. 2001) and that this is assumed to be a
key site of dysfunction in fvFTD (Rahman et al. 1999), it is important to
attempt to understand the changes effected by paroxetine in this area.
Blier and de Montigny (1998) found that the evoked release of tritiated
5-HT in the guinea pig was significantly enhanced in the OFC after an 8-week
course of high-dose paroxetine or fluoxetine but not after 3 weeks.
Although a 4-to-6-week study period is conventional for testing the
efficacy of a treatment for depression, 8–12 weeks is typically used in
assessment of SSRI treatment of obsessive–compulsive disorder (Montgomery
1996).
It is possible that a longer course of paroxetine could produce
different results on neuropsychological measures and perhaps even
subjective measures." -
Paroxetine does not improve symptoms and impairs cognition in
frontotemporal dementia:
a double-blind randomized controlled trial, Psychopharmacology (2004)
172:400–408 DOI 10.1007/s00213-003-1686-5, J. B. Deakin, S. Rahman, P. J.
Nestor, J. R. Hodges, B. J. Sahakian
1987 to
1996
Psychotropic chemical use among children and teens nearly
triples.
1997 Joseph Westbecker, prescribed
Prozac®, kills himself and eight others at a Louisville, Kentucky printing
plant after being fired.
Eli Lilly settles charges and the judge seals
the case.
1998 Andrew Golden, age 11,
Ritalin® and Mitchell Johnson, aged 14, Ritalin® shot 15 people,
killing four students, one teacher, and wounding 10 others.
Kip Kinkel,
age 15, (on Prozac® and Ritalin®) shoots his parents while they sleep
then goes to school and opens fire killing 2 classmates and injuring 22 shortly
after beginning Prozac®
treatment.
1999 Eric
Harris age 17 (first on Zoloft® then Luvox®) and Dylan Klebold age 18,
kill 12 students and 1 teacher, and wound 23 others, before killing themselves.
Klebold's medical records have never been made available to the
public.
TJ Solomon, age 15, Ritalin® high school student in Conyers,
Georgia opens fire on and wounded six of his class mates.
"In summary,
emotional blunting associated with SSRI treatment may be more common than
previously thought.
Further study is required to determine the
frequency of this phenomenon, whether it is associated primarily with SSRI
antidepressants, whether usually associated with the presence of sexual
dysfunction, and what the functional implications of these symptoms are.
We speculate that in some patients, rather than representing a
side-effect, blunting of emotional response
may be the central therapeutic effect of SSRIs." - Emotional blunting associated with SSRI-induced sexual
dysfunction. Do SSRIs inhibit emotional responses?
2001
Christopher Pittman, age 12, murders both his grandparents while taking
Zoloft®
Kara Jaye Anne Fuller-Otter, age 12, is on Paxil® when
she hangs herself from a hook in her closet.
"The damn doctor wouldn't
take her off it and I asked him to when we went in on the second visit. I told
him I thought she was having some sort of reaction to Paxil®." - Kara's
mother
Cory Baadsgaard, age 16, Wahluke High School, had recently
switched to the new antidepressant Effexor, amping up his dosage from 40
milligrams to 300 which caused him to have
hallucinations
when he took a rifle to his high school and held 23 classmates hostage.
He has no memory of the event.
2002 157
million antiDepressant prescriptions are dispensed in America:
Sertraline, Zoloft®, Lustral®, Serlain®, Paroxetine,
Paxil®, Seroxat®, Sereupin®, Aropax®, Deroxat®,
Rexetin®, Xetanor®, Paroxat®, Fluoxetine, Prozac®, Fontex®,
Seromex®, Seronil®, Sarafem®, Fluctin®, Fluox®,
Depress®, Lovan®, Citalopram, Celexa®, Cipramil®, Dalsan®,
Recital®, Emocal®, Sepram®, Seropram®, Citox®.
"The
pharmaceutical industry often touts its commitment to research to benefit
patients.
Internal pharmaceutical industry documents suggest a
different motivation for research.
An
internal document from Pfizer states that research is done to "Optimize our
ability to sell Zoloft [sertraline] more effectively... the purpose of data is
to support, directly or indirectly, marketing of our product."
An Eli
Lilly document states that the company should: "Develop scientific research and
publications plan that enhances credibility of the new positioning and enables
the achievement of the ideal positioning ... Mine existing data to generate and
publish findings that support the reasons to believe the brand promise." - Glen
Spielmans
In The Illusion of Evidence-Based Medicine: Exposing the
crisis of credibility in clinical research Jon Jureidini and Leemon B
McHenry describe problems with two industry-funded antidepressant randomised
controlled trials.
Study 329 examined paroxetine and was funded by
SmithKlineBeecham (now GSK); and CIT-MD-18 was a citalopram trial funded by
Forest Laboratories.
Internal communications show
sponsors knew efficacy results were negative, yet
journal articles and
marketing efforts claim treatment efficacy.
Adverse events were
also mischaracterised and underreported.
Marketing clearly trumped
science, which is stated bluntly in several internal communications described
by Jureidini and McHenry.
Those who control evidence control evidence based
medicine
2003 Over 30
million Americans take antidepressant chemicals, Prozac®, Zoloft®,
Paxil®, Luvox®, Celexa®, Lexapro®, Effexor®,
Wellbutrin®, Serzone® and Remeron®.
The first seven are
'serotonin reuptake inhibitors,' and their sales exceeded those of any other
chemical class except opiates.
2004 FDA warns
physicians, patients and their families that popular antiDepressant can cause
deepening depression
and even suicide.
AntiDepressant
use has been associated with agitation,
hostility, mania and
other forms of violent and/or antiSocial behavior.
Violence and Suicide Caused by antiDepressant Report to the
FDA
Rick Lohstroh's 10 year old son, on Prozac®, shoots his
father dead.
The boy is given a 10 year prison sentence.
Alex
Kim, age 13, hangs himself when his Lexapro® prescription is
been.
"Reporting of
medical errors affecting children is a significant problem, particularly among
physicians." - Agency for Healthcare Research (AHRQ)
2005 Jeff Weise, age 16, prescribed 60 mg/day of Prozac (three
times the average starting dose for adults!) shoots his grandfather, his
grandfather's girlfriend and many fellow students at Red Lake, Minnesota.
He then shot himself. 10 dead, 12 wounded.
2007 Asa Coon, Cleveland, age 14, wounds four before killing
himself.
Court records show Coon was on Trazodone®.
2010 Hammad Memon, age 15, shoots and kills a fellow student.
Hammad has been diagnosed with ADHD and depression, prescribed
Zoloft® and "other chemicals for the mental disorders."
and
then:
Gabriel Myers, 7 years
old, hangs himself while in foster care.
Gabriel was prescribed
Vyvanse®, an attention deficit/hyperactivity
disorder chemical for children aged 6 through 12, Lexapro®, an
anti-depressant, and Zyprexa®,
an antiPsychotic
chemical - both not approved for children.
Symbyax®, an
atypical antiPsychotic approved by the FDA for the
treatment of
schizophrenia, is prescribed to replace Lexapro® and Zyprexa®
shortly before Gabriel Myers death.
Gabriel's mother is in prison for
chemical abuse.
''We are devastated. Gabriel's problems could not be
solved by a pharmacy.'' - Jon Myers, Gabriel's uncle
Chris Fetters,
age 13, kills his favorite aunt while taking Prozac®.
Elizabeth Bush, age 13,
Paxil® is responsible for a school
shooting in Pennsylvania.
Mathew Miller, age 13, hangs himself in his
bedroom closet after taking Zoloft® for 6 days.
Rod Mathews, age 14,
Ritalin® beats a classmate to death with a
bat.
Michael Carneal, age 14, Ritalin® opens fire on students at a
high school prayer meeting.
Jarred Viktor, age 15, after five days on
Paxil® stabs his grandma 61 times.
Chris Shanahan, age 15,
Paxil® in Rigby, ID kills an unfamiliar woman.
Luke Woodham, age
16, Prozac® kills his mother and then kills two students, wounding six
others.
Jon Romano, age 16, on medication for depression, fires a
shotgun at a teacher in his New York high school.
Julie Woodward, age
17, is on Zoloft® when she hangs herself in her family's detached garage.
Kurt Danysh, age 18, on Prozac®, kills his father with a shotgun.
Kurt is now behind prison bars.
Kurt now writes letters, trying
to warn the world that SSRI can kill.
"Emergence of self-destructive phenomena in children and adolescents
during fluoxetine treatment," published in the Journal of the American
Academy of Child and Adolescent Psychiatry (1991, vol.30), written by RA
King, RA Riddle, et al, reports self-destructive phenomena in 14% (6/42) of
children and adolescents (10-17 years old) who had treatment with fluoxetine
for obsessive-compulsive disorder.
"In the last few years
the psychiatric field has been
characterized by very expensive chemicals, which, at best, are not inferior to
previous chemicals.
To give an example: escitalopram (from citalopram),
paliperidon (from risperidon), mirtazapine (from mianserine), pregabalin (from
gabapentin), etc.
Many new
antiPsychotics
aren't better than older ones for effectiveness or
side effects." - Vincenzo
Fricchione Parise 02/06/09
2008
Journal of the American Medical
Association finds reporters fail 42% of the time to mention
PHRMA funding of research cited in
"news" stories.
67%
of "news" stories mention brands of
chemicals rather than generic chemical names, reinforcing PHRMA marketing
campaigns.
In Toxic Psychiatry, Dr. Peter Breggin discusses the
subject of chemical combinations:
"Combining antiDepressant [e.g.,
Prozac®, Luvox®] and psychostimulants [Ritalin®] increases the risk
of serious cardiovascular
seizures and psychosis.
Withdrawal from the
combination can cause a
severe reaction
that includes confusion,
emotional instability, agitation, and aggression."
"I approached ACLU
about the fact that there are people in
prison who are likely there because their chemicals caused them to become
violent but didn't even get an acknowledgment from ACLU that I had
written." - Dr. David Healy, professor of psychiatry and Secretary of
British Association for Psychopharmacology, author of Let Then Eat
Prozac and Mania
sedatives
"Observers are alarmed by
what they are finding as they track patients for months or years after an ICU
stay.
Patients, even young ones, can be weak for years.
Some
have difficulty thinking and concentrating or have
post-traumatic stress disorder
and terrible memories of nightmares they had while heavily sedated.
Observers are increasingly convinced that spending days, weeks or
months on life support in the units can elicit unexpected, long-lasting
effects." - Gina Kolata, January 11, 2009
Dr. O. Joseph Bienvenu
worries about post-traumatic stress
disorder.
Many remember nothing, others
cannot forget horrifying
hallucinations.
Mechanical ventilator tubes
and machine hookups are
terrifying.
Their illnesses produce
delirium, but so do the drugs used in sedation.
"One man told me he saw
children's faces that were blacked out and blood running down the walls," Dr.
Bienvenu said. "He thought he'd been
kidnapped and
tortured. One woman said she
saw her husband and a nurse talking, and she thought they were plotting to kill
her."
Scientists are beginning to worry about the effects of simply
being in an intensive care unit, on a mechanical ventilator that pushes oxygen
under pressure in and out of the lungs, receiving doses of sedatives, narcotics
and anesthetics high enough to make even healthy people stop breathing on their
own (patients who are resting and sedated are also given less oxygen).
They have been
particularly surprised by how quickly patients lost strength.
It
looks like what was lost may not completely come back, even years later.
Dr. John Kress, director ICU
University of Chicago,
wondered whether the sedatives keeping patients comfortable might be making
them worse.
They woke patients briefly every day by turning off the
infusion of sedatives.
Patients actually had significantly lower rate
of post-traumatic stress
disorder, which is manifested by such things as
mood disorders,
anxiety,
difficulty concentrating,
shortness of temper and
frightening
memories.
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