2009 There are 1800 foreign funded pharmaceutical enterprises
in China. The top 20 pharmaceutical companies
set up joint ventures or wholly owned facilities in China. This suggests
that market conditions have never been more challenging, with
competition at an all-time
produces and markets more than 40 drugs in China all of which meet chinese
pharmacopeia quality control.
Pfizer has manufacturing
facilities in Dalian, Suzhou and Wuxi. The Pfizer Dalian
facility, built in 1989 jointly with Dalian Pharmaceuticals was the
first to get certification in China.
GlaxoSmithKline has more than
2000 employees in China, and its drugs are sold in 60 cities. GlaxoSmithKline mainly
sells drugs treating HIV,
asthma and infection.
Merck sells antibiotics
prostate drugs, cardiovascular drugs,
pain relievers, osteoporosis
and vaccines. Merck set up its first
joint venture in China in 1994.
Novartis has four
manufacturing facilities in Beijing and Shanghai. Novartis core businesses
involve patented drugs,
generic drugs, eye protection drugs and
health products. Novartis Beijing was founded by Novartis AG and
Beijing Pharmaceutical group and Beijing Zizhu Pharmaceuticals in
1987 and was the first foreign pharmaceutical company in China.
German-French company, sells several drugs in China.
AstraZeneca has headquarters in
Shanghai, with 25 branch offices in major cities. In 2001
AstraZeneca established its largest
manufacturing site in Asia in Wuxi. AstraZeneca sells
several products, including the
antiPsychotic used in the management of
Seroquel(quetiapine) and Nexium(esomeprazole).
AstraZeneca has nearly 3,000 employees working in manufacturing,
research and new product development.
AstraZeneca has a
presence in more than 110 targeted cities, with around
Bristol-Myers Squibb was one of the
earliest to enter Chinese market.
Johnson & Johnson has
established subsidiaries which include Shanghai Johnson & Johnson
Pharmaceuticals, Ltd, Johnson & Johnson Medical (Shanghai) Ltd,
Johnson & Johnson Medical (China) Ltd, Johnson & Johnson
(China) Ltd, Johnson & Johnson (China) Investment Co., Ltd,
manufacturing and selling drugs in China.
Wyeth best-seller in China includes
Roche launched a medical education campaign
targeting 3,500 doctors in 20 Chinese cities in 2004.
Schering-Plough is the recognized leader
in biotech, genomics and gene therapy. Shanghai Schering-Plough
Pharmaceutical Co., Ltd was founded in 1994 as a joint-venture, with
Shanghai Pharmaceutical Industry (Group) Corporation and Shanghai
Corporation of Pharmaceutical Economic and Technical International
Bayer's invested in the early 1990s in large-scale,
world-class facilities in an integrated production site in the Shanghai
Chemical Industry Park. Bayer's operations, in Hong Kong, Taiwan, and China
are led by management holding companies, with subgroups and production joint
ventures operating independently under Bayer's strategic direction.
Bayer has production facilities on stream in all corporately
active business lines. Chinese production accounts for an increasing proportion
of profit margins. Bayer is engaged in a number of cooperation projects with
some of the foremost research institutes and universities in China, to conduct
research in the field of innovative materials, health care and crop science.
Bayer cooperates with the Chinese Academy of Science and affiliated
institutes such as the Institute of Materia Medica and the Kunming
Institute of Botany in Yunnan with the aim to identify new compounds in the
healthcare and crop science field. There are also a number of projects
currently being started in polymers research.
Bayer supports a number of chairs and programes for
research and teaching at Chinese universities. These include the
Tsinghua-Bayer Public Health and HIV/AIDS Media Studies Program,
a national platform designed to play a key role in China's public health
system. Bayer HealthCare supports a chair for Healthcare Management
at the China European International Business School (CEIBS) in Shanghai.
Boehringer Ingelheim entered Chinese market in 1995 and invested
$25 million in a new facility in Shanghai in 2002. Its drugs treating
respiratory diseases and
are established in Chinese pharmaceutical markets.
russell established its China head offices in Beijing in 1995 to manage
operations in mainland China and Hong Kong. Hoechst Marion russell has
two joint ventures in China, Hoechst Huabei Pharmaceuticals Ltd in
Shijiazhuang, a heartland of the Chinese pharmaceutical industry, and
Hoechst Shanghai International Pharmaceuticals Ltd.
Eli Lilly set up
its first overseas office in Shanghai in 1918 and returned to Shanghai, China
in 1993. Eli Lilly
main facility is in Suzhou, Jiangsu province and main products include cipro,
insulin, and erectile
Abbott Laboratories Ltd sells a series of
products including baby food in China.
foreign-invested ventures in China, Xian-Janssen Pharmaceutical's
success is due to its product line, which includes a range of high-volume
sellers: medicines to treat gastronintestinal problems, fungi,
allergies and pain, as well as
Dr. Paul Janssen's
decision to enter China early, to
invest inland, and to keep investment plans moving along in the wake of 1989
Tiananmen Square event have helped build good relations with the Chinese
government. Paul Appermont and Joos Horsten lead the Xian-Janssen
Degussa is shifting a large
proportion of its pharmaceutical chemicals production from Europe to China in
order to take advantage of low-cost manufacturing. Degussa will
restructure its large production facilities, the vast majority in Germany,
which could result in the transfer of the manufacture of other products to
Rhodia is improving its competitive position in
analgesics by making a major investment in its Wuxi, China acetaminophen
(paracetamol) production facility and consolidating its North American and
European operations. Rhodia shuttered its Luling, Louisiana,
acetaminophen (paracetamol) operations in 2004 and consolidated production in
Roussillon, France and Wuxi, China. Acetaminophen (paracetamol) production
capacity will be adjusted to match current consumption levels.
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Sankyo has operated a plant for manufacturing the
hyperlipemic Mevalotin(pravastatin), anti-inflammatory
Loxonin(loxoprofen), antibiotic Banan(cephalosporin antibiotic)
and has plans to market hypertensive Olmesartan(angiotensin II receptor
Takeda has a manufacturing plant and will be
marketing all four global products - the thiazolidinedione with hypoglycemic
action Actos(pioglitazone), anti-ulcer proton pump
inhibitorTakepron(lansoprazole), gonadotropin-releasing hormone agonist
cancer drug Leuplin(leuprolide acetate), and hypertensive
Yamanouchi owns a manufacturing
plant and is marketing anti-ulcer histamine H2-receptor antagonist
Gaster(famotidine), urinary impediment treatment
Harnal(tamsulosin), a selective alpha blocker used in the symptomatic
treatment of benign prostatic hyperplasia and hypertensive calcium channel
blocker Hypoca. There are plans to launch Dolner for peripheral
circulation and anti-emetic Nazea OD.
sells synthetic antibacterials Cravit (oral and injectable levofloxacin)
and Tarivid(ofloxacin). It originally planned to launch
neurotransmission enhancer Translon too, but after development was
halted in Japan, development in China also ended. Sales are behind plan chiefly
due to the suspension of Translon's development and the proliferation of
generic and copycat versions of
Tanabe markets hypertensive
Herbesser(diltiazem hydrochloride) and Tanatril (imidapril
The China subsidiary Kuangchou Green Cross of
Mitsubishi Pharma has been extending transfusion business
(manufacturing, sales) since the days of the former Green Cross.
Mitsubishi Pharma sold its transfusion business in Japan to Otsuka
Pharmaceutical as part of a restructuring. Anti-coagulant
Novastan(argatroban) was launched in China in December 2002 and is being
sold by a local agent.
Immunosuppressant Prograf(tacrolimus or
fujimycin) is being marketed in China by a Fujisawa subsidiary -
potential is significant due to the ever increasing number of organ
transplants. In 2000, there were 5,501 kidney transplants performed in China,
second only to the number in the US (13,372). Sales of immunosuppressant drugs
are relatively high. The top 30 drugs by sales in China (hospital market base)
included two such drugs: Novartis' immunosuppressant drug used in
post-allogeneic organ transplantNeoral(cyclosporine) and Roche's
immunosuppressant drug used to prevent rejection in organ transplantation
CellCept (mycophenolate mofetil).
Chugai exports white
blood cell production stimulant Neutrogin (lenograstim) to China.
Kirin's granulocyte colony-stimulating factor is marketed in
Eisai expanded its manufacturing and marketing operations
in China and Asia earlier than in the European and US markets. Eisai was
the first manufacturer among the US, European and Japanese pharmaceutical firms
to manufacture in China via a 100% owned subsidiary which founded in 1994.
Eisai sells two global products, anti-ulcer proton pump inhibitors
Pariet(rabeprazole) and Alzheimer's acetylcholinesterase inhibitor
treatment Aricept(donepezil), and plans to add
Glakay(menatetrenone) in 2006.
Kyowa Hakko has exported
cancer drugs and plans to market the hypertensive dihydropyridine calcium
channel blockerConiel(benidipine) and anti-allergy antihistamine and
mast cell stabilizer Allelock(olopatadine
Taisho makes and sells health drinks (tonics) in
China, but has no specific plans for prescription medications. The rights to
macrolide antibiotic Clarith/Biaxin(clarithromycin) outside Japan
are licensed to Abbott.
Terumo is using China as a
manufacturing base making products for the US and European and Japanese
markets. Terumo is in the process of exploring China as a
The first foreign office of the
FDA opened November 19,
2008 in Beijing.
2009 McNeil Consumer Healthcare, a division of Johnson &
Johnson, announced the recall of several hundred batches of popular
over-the-counter medicines, including Benadryl, Motrin, Rolaids, Simply Sleep,
St. Joseph Aspirin and Tylenol.
The response was anything but swift.
The recall came 20 months after McNeil first began receiving consumer
complaints about moldy-smelling bottles of Tylenol Arthritis Relief
Johnson & Johnson did not conduct a timely, comprehensive
investigation, did not quickly identify the source of the problem, and did not
notify authorities in a timely fashion thus prolonging consumer exposure to the
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