simian foamy virus (SFV), a spumavirus, has been co-speciated with Old World
primates for about 30 million years, making them the oldest known vertebrate
RNA (ribonucleic acid) or
late 1950's SV40, a retrovirus,
is identified in the injected form of the polio
This is believed to be due to kidney cells from infected
monkeys being used to amplify the vaccine virus during production.
the Sabin vaccine (oral, live virus) and the Salk vaccine (injectable, killed virus) are
affected; the technique
used to inactivate the polio virus in the
Salk vaccine, by means of
not reliably kill SV40.
When two or more vaccines are mixed together in
the same formulation, the two vaccines can interfere.
frequently occurs with live attenuated vaccines, where one of the vaccine
components is more robust than the others and suppresses the growth and immune
response to the other components.
This phenomenon was first noted in
the trivalent Sabin polio vaccine, where the amount of serotype 2 virus in the
vaccine had to be reduced to stop it from interfering with the "take" of the
serotype 1 and 2 viruses in the vaccine.
SIVagm is a lentivirus also a
The genome consists of two
strands, a longer negative-sense strand and a shorter and positive-sense strand
of variable length.
In the virion these strands are arranged such that
the two ends of the long strand meet but are not
covalently bonded together.
virus binds to receptors allowing viral particles to enter the cytoplasm.
This is then translocated to the nucleus, where the partially double
stranded DNA is 'repaired' by the viral polymerase to form a complete circular
dsDNA genome (called covalently-closed-circular DNA or cccDNA).
genome then undergoes transcription by the host cell RNA polymerase and the
pregenomicRNA (pgRNA) is sent out of the nucleus.
The pgRNA is inserted
into an assembled viral capsid containing the viral polymerase.
this capsid the genome is converted from RNA to pdsDNA through activity of the
polymerase as an RNA-dependent-DNA-polymerase and subsequently as an RNAse to
eliminate the pgRNA transcript.
These new virions either leave the cell
to infect others or are immediately dismantled so the new viral genomes can
enter the nucleus and magnify the infection.
The virions that leave the
cell egress through budding.
This is a deoxyribonucleic acid virus.
late 1960s Researchers "isolate" and
then inoculate with the MS-2 strain of hepatitis
Hepatitis viruses replicate through an RNA intermediate
form by reverse transcription, and in this respect they are similar to
Hepatitis B virus belongs to the Hepadnavirus family.
Hepadnaviruses have very small genomes of partially double-stranded,
partially single stranded circular DNA.
1970s African rhesus monkeys are used in the manufacture of the
hepatitis B vaccine.
Human hepatitis B
viruses cultured in vivo in
rhesus monkeys are returned to humans whose infected blood serum is then pooled
to develop four different strains of experimental hepatitis B vaccine.
This experimental vaccine is pilot tested in New York City and central
Hepatitis B vaccine recipients
worldwide, including gay men in New
York, and Black Africans in Central Africa, are exposed to simian viruses
including SV40, SIVagm, and perhaps others.
A generally neglected
evolutionary route of SIVagm to HIV-1 zoonosis sequentially involves:
human incubation for more than a decade of polio vaccine contaminants and
recombinants including SV40, SFR, and possibly SIVagm;
b) the pooling of
infected blood serum donated by hundreds of gay American and Black African
hepatitis B vaccine
recipients who had subsequently received injections with
cultured strains of hepatitis B
c) the biohazardous laboratory conditions and viral
containment problems reported by the hepatitis B vaccine investigators and
This series of events provides the best explanation
for an early to mid-1970s "punctuated origin event" most precisely fitting
determinations of the HIV-1/AIDS pandemic.
There is evidence demonstrating that the
associated retrovirus (SZRV) is an autoimmune causing retrovirus in the
Type-D family of retroviruses, e.g., SRV-1 (simian retrovirus type 1), SRV-2
(simian retrovirus type 2), M7 (baboon endogenous retrovirus), SMRV-H (squirrel
monkey retrovirus), HTLV (human T lymphocyte leukemia virus) and
distantly-related to HIV (human immunodeficiency
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