Schizophrenia is a disease of salience.
brain loses the ability to tune out information that isnt useful or
"Patients sometimes say they used to be able to read
books, now they cant read books. They cant sustain focus. They used
to build models, now they dont. They used to be able to play the guitar
well, now thats deteriorated." - Daniel Mathalon, UCSF
"They are walking down the street trying to have a
conversation and their brain is being flooded with the sound of the door
slamming, the airplane going overhead," says Sophia Vinogradov, a
psychiatrist and researcher at the San Francisco VA hospital.
brain is starting to process all of that information as if it has meaning, and
is something the brain needs to pay attention to and needs to do something
Why and how normal people go mad
Hypothyroidism Presenting as
The social engineering
idea of segregating out those people considered unfit to reproduce dates back
to antiquity and may have biological underpinnings.
hypothesis that early
humans violently replaced Neanderthals through genocide was proposed by French
palaeontologist Marcellin Boule in 1912.
Septuagint describes the
Amalekites a supposedly degenerate group that God condemned to death for
living in a unclean depraved
"While the Jews were still in Rephidim, the Amalekites, a
mightily and fierce people, descendants of Esau, and well-trained in the art of
warfare, suddenly attacked the people of Israel. The battle lasted a whole day
until the Amalekites were finally defeated and routed. An oath was taken to
wipe the Amalekites - the incarnation of all evil -
off the face of the earth.
There could be no peace between Israel and Amalek for all time to come." -
Fitness at this point in time requires
the ability to serve God the
At this time in human history there is always an
assigned to stand in stead of God as
the Caretaker and Patriarch of the
Even though the position is assigned each asignee has the
choice to serve either Wakan
Takan or, if they have chosen the dark path,
Intelligence quotient becomes intricately related to the ability to
340 BC Aristotle composes The Art of Rhetoric.
"Rhetoric then may be
defined as the faculty of
discovering the possible means of persuasion
in reference to any
subject whatever." - Aristotle
Aristotle lays out 3 types of
persuasion that can be used in public settings.
Ethos, Pathos, and Logos
are the modes used to convince audiences.
ethical appeal - to
convince an audience of expert
Pathos or emotional appeal - to
emotional manipulation of an
Logos or appeal to logic - to
convince an audience by linear
Aristotle defines 3 ways the Art of Persuasion can
be used in public settings.
In classical rhetoric, oratory is divided
into three branches: judicial oratory (or "forensic"); deliberative oratory (or
"legislative") and epideictic oratory ("ceremonial" or
Aristotle stresses that rhetoric is closely related to
Council of Trent states
that celibacy and virginity are superior to marriage.
early 1700s Concerns about environmental influences that might
damage heredity leading to ill health, early death, insanity, and
defective offspring are formalized as degeneracy theory.
then called onanism, is presented in allopathic medical schools as the first
biological theory of the cause of degeneracy.
maintain a strong following until late in the 19th century.
1857 Bénédict Morel published degeneration
theory Traité des dégénérescences
Morel includes images of twelve patients that demonstrat
the physical, mental, and moral traits as evidence of degeneration.
Some of these characteristics included altered ear shape, asymmetrical
faces, extra digits, and high-domed palates with psychological
Foundation of degeneration theory: psychological
disorders are genetic.
Bénédict Morel extends the causes
of degeneracy to some legitimate agents including poisoning by
ergot, and other toxic
Most scientists believe toxic environments cause degenerate
1877 The sociologist Richard
Dugdale believed that good environments could
into worthy citizens within three generations.
This position was
the backdrop to his influential study on The Jukes, a degenerate family
of paupers and petty criminals in Ulster County, New York.
1883 Francis Galton coins the term eugenics perceiving it as a
moral philosophy to improve humanity by
encouraging the ablest and healthiest people to have more children.
Galtonian ideal of eugenics is termed positive eugenics.
eugenics, on the other hand, advocated culling the least able from the breeding
population to preserve humanity's fitness.
The eugenics movements in
the US, Germany, and Scandinavia favor the negative approach.
1893 August Weismann studied how the traits of organisms
developed and evolved in a variety of organisms, mostly insects and aquatic
animals and publishes Das Keimplasma (germ plasm).
theory dovetailed into his work when he recognized a gradual loss of genetic
information which occurs commonly in zoos and microbiology labs.
This basic inbreeding problem Weismann
framed as naturally occuring.
Theory of the germ plasm
convinces scientists changes in body tissue (soma) have little or no effect on
reproductive tissue (germ plasm).
Inheritance in a multicellular
organism must take place by means of germ cells: gametes - egg cells and sperm
cells - inheritance is unaffected by environment.
It is theorized soma
cannot pass information to germ plasm and other cells are unable to influence
The Weismannian notion that the germ cells are unaffected by
somatic cells or their environment has proven incorrect.
modification of the nucleotide bases that constitute the genetic code such as
methylation of cytosines as well as modifications of the histones around which
DNA is organized into higher-order structures are influenced by the metabolic
and physiologic state of the organism and may be inheritable.
Epigenetic changes alter the
1899 Fear of degeneracy
leads Harry Clay Sharp, a prison physician in Jeffersonville, Indiana, to carry
out vasectomies on prisoners.
The advocacy of Sharp and his medical
colleagues, culminates in an Indiana law mandating compulsory sterilization of
1900 The model of August Weismann
is eagerly adopted by degeneracy theorists who embrace negative eugenics as
their favored model.
1904 Alfred Binet and Theodore Simon develop the first modern
intelligence test in IQ history.
The French Ministry of
Education asked the researchers to develop a test that would allow for
distinguishing mentally retarded children from
but non-compliant children.
1907 The first eugenic
sterilization law in the US enacted.
Adherents of the new field of
genetics were ambivalent about eugenics.
William Bateson in Great Britain, Thomas Hunt Morgan in the US
shun eugenics as a vulgar
unproductive field of research.
Unfortunately, Bateson's and Morgan's
contribution to basic genetics is quickly absorbed by eugenicists, who take an
interest in Mendelian analysis of pedigrees of humans, plants and animals.
Many eugenicists had
some type of agricultural background.
Charles Davenport and Harry
Laughlin introduced by a shared interest in chicken breeding ran the
Eugenics Record Office.
Both were active in Eugenics Section of
the American Breeder's Association (ABA).
Eugenics: The Science of Human Improvement through Better Breeding, had
a distinct agricultural flavor, and his affiliation with the ABA was included under
his name on the title page.
Agricultural genetics also
provided the favored model for negative eugenics: human populations, like
agricultural breeds and varieties, had to be culled of their least productive
members, with only the healthiest specimens used for breeding.
Evolutionary models of natural
selection and dysgenic (bad) hereditary practices in society also
contributed to eugenic theory.
was fear that highly intelligent people would have smaller families (about 2
children), while the allegedly degenerate elements of society were having
larger families of four to eight children.
Public welfare might
also play a role in allowing less fit people to survive and reproduce, further
upsetting the natural selection of fitter people.
Medicine also put its
stamp on eugenics.
Physicians like Anton Ochsner and Harry Sharp were
convinced that social failure was a medical problem.
criminologist and physician Cesare Lombroso popularized the image of an innate
criminal type that was thought to be a reversion or atavism of a bestial
ancestor of humanity.
When medical means failed to help the
psychotic, the retarded,
the pauper, and the vagrant, eugenicists shifted to preventive medicine.
The German physician-legislator Rudolph Virchow, advocated programs to
deal with disease
prevention on a large scale.
Virchow's public health movement was
fused with eugenics to form the racial hygiene movement in Germany and
came to America through physicians he trained.
Eugenicists argued that
"defectives" should be prevented from breeding, through custody in asylums or
Many doctors felt that sterilization was a
more humane way of dealing with people who could not help themselves.
Vasectomy and tubal ligation were favored methods, because they did not
alter the physiological and psychological contribution of the reproductive
Sterilization allowed the convicted criminal or
mental patient to
participate in society, rather than being institutionalized at public
Sterilization was not viewed as a punishment because these
doctors believed (erroneously) that the social failure of "unfit" people was
due to an irreversibly degenerate germ plasm.
1910 Henry Herbert Goddard bring Binet's test to the US.
Goddard believes intelligence is a fixed quantity.
1916 Stanford University psychologist Lewis Terman
standardized Binet's original test using a sample of American participants.
Stanford-Binet Intelligence Scale became the standard used in
The IQ score was calculated by dividing the test taker's mental
age by his or her chronological age and then multiplying this number by 100.
For example, a child with a mental age of 12 and a chronological age of
10 would have an IQ of 120 (12/10 x 100).
Children who had exceeded the
average of their age group were said to have a higher "mental age" while those
who performed below that average were deemed to have a lower "mental
1955 David Wechsler publishes the
Wechsler Adult Intelligence Scale.
Data collection for the next
version (WAIS 5) began in 2016 and is expected to end in spring
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